Hematopoetic stem cell transplantation for pediatric non-hematological solid tumors

Hauser Péter (1), Kriván Gergely (2)
(1) Semmelweis Egyetem, II. sz. Gyermekklinika, Budapest
(2) Egyesített Szent István és Szent László Kórház-Rendelőintézet, Gyermekhematológiai és Őssejt-transzplantációs Osztály, Budapest

High-dose chemotherapy followed by stem cell rescue or allogeneic stem cell transplantation in the treatment of solid tumor with non-hematologic origin applied for more than three decades. High-dose chemotherapy with stem cell rescue is the part of standard first line therapy for several chemosensitive tumors with unfavorable outcome (neuroblastoma, Ewing-sarcoma, medulloblastoma), and also successfully applied in certain therapy-resistant or recurrent solid tumors (germ cell tumors, Wilmstumor). Allogeneic transplantation with reduced intensity conditioning is still not successful in terms of survival in pediatric solid tumors with non-hematological origin. In present paper results of autologus and allogeneic stem cell transplantation in different pediatric solid tumor are discussed.