Precision medicine in radiation oncology

Dobi Ágnes (1), Kószó Renáta Lilla (1), Besenyi Zsuzsanna (2), Gion Katalin (2,3), Hideghéty Katalin (1,4)
(1) SZTE SZAOK Onkoterápiás Klinika, Szeged
(2) SZTE SZAOK Nukleáris Medicina Intézet, Szeged
(3) Komplex Labor Diagnosztika Kft., Szeged
(4) ELI-ALPS Non-profit Ltd.

Radiation therapy, as an eliminative treatment, is an important component of complex antitumour therapies. From the very beginning, it has evolved as a procedure applied to the anatomy and tumour type of a given patient, resulting in individually tailored radiation treatment. Technological advances and research results have made it possible in recent decades to delineate more precise target volumes and to make dose delivery more selective. In radiotherapy, in the age of precision medicine, technology-driven treatments, including advanced imaging and particle therapy, and the introduction of new biological concepts can greatly enhance the therapeutic index, the proportion of tumour destructing and healthy tissue protecting effects. Modern precision oncoradiology embraces the determination of radiation sensitivity parameters of the individually identified tumour- and normal tissues, as well as of certain tissue parts, and the prediction and monitoring of the expected effects. In our publication, we aimed to present the use of various genomic, radiomic and functional studies, and data sets processed with the help of modern informatics in the planning and adaptation of personalized radiotherapy.

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