Tumoragnostic therapy in the pediatric oncology

The diagnosis and therapy of childhood malignant tumors have undergone rapid development in recent years. Most childhood cancers are treated in accordance with international protocols, providing good survival rates to the patients. At the same time, the prognosis of advanced-stage or relapsed diseases remains challenging. In addition, treatment recommendations based on large, international studies are lacking in rare tumors with the prognosis of these diseases being often less favorable. Tumor-agnostic therapy is a promising treatment option based on precision oncology methods. It offers a new therapeutic strategy irrespective of the histological type of the tumor, by targeting the genetic characteristic of the cells. In our report, we present the advantages and challenges of tumor-agnostic treatments for pediatric extracranial tumors.